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While the intense basal level of infiltrated neutrophils and the establishment of bacterial infections are primary contributors to the generation of ROS in CF, the underlying cellular dysfunction provides additional, intrinsic sources of oxidative stress

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For example, metabolomics can identify biomarkers associated with specific diseases, aiding in early diagnosis and monitoring disease progression [272, 273]

Opioids were designed to reach receptors in the brain, causing pain reduction and feelings of euphoria