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Baseline PD-L1 surface expression in both Myc-CaP and 22Rv1 prostate cancer cells was low, and IGF-1 stimulation did not result in a clear increase in surface PD-L1 levels in 22Rv1 cells (Supplementary Figure S5B-C)

These mechanisms address different root causes of weight gainmetformin tackles insulin resistance, and semaglutide reduces hunger and caloric intake

The study highlights that patient-reported data from social media may capture experiences that are not consistently documented in formal adverse event reporting systems

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