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No GHK-Cus mechanism targets tissue remodeling through fibroblast activation and matrix metalloproteinase regulation, which requires localized tissue concentration, not systemic plasma levels

These observations, reflecting regulatory effects on the transcriptional control of transporters affecting brain UA, demonstrate tissue-specific effects on UA activity, which further question the validity of MR studies discussed above

Segatore B

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The authors point out that doxycycline-associated skin hyperpigmentation seems to be uncommon and they summarize 18 patients in the literature with this side effect