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Patients with IBD are also characterized by gut microbiome dysbiosis

Oct 2019;17(10):721-728

Initially the bioavailability of marker compounds was determined by administrating the pure marker compounds individually to Wistar rats by oral (dose 15 mg/kg b.w per oral) and parenteral (dose 1.5 mg/kg b.w i.v.) routes, followed by determination of content of the same in plasma at different time points by the HPTLC method

However, concurrent hypermetabolism, hypercatabolism, and hypoanabolism provoked by systemic inflammation and catabolic factors, not reversed by conventional nutritional support, lead to progressive and irreversible impairment