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2024;10(10):Cd11800

1a) and superior to the peptide antagonist exendin (9-39) 30

Heres what happened: Starting point: Weight: 89.5kg Body fat: 15% Fat mass: 13.4kg Muscle mass: 73.5kg Visceral fat: Level 5 (relatively low) After 3 months: Weight: 77kg Body fat: 8.3% Fat mass: 6.8kg Muscle mass: 71.1kg Visceral fat: Level 2 Total changes: Weight lost: 12.5kg Fat lost: 6.6kg (over a stone of pure fat) Muscle lost: 2.4kg (mostly water, not actual muscle tissue) Visceral fat reduction: 60% Cardiovascular fitness: VO2 max improved from 51 54 (significant increase) Strength: Lost 10-15% on main lifts (bench press, squats, pull-ups)

A naturally occurring hormone called FGF21 may help reverse obesity, not by making you eat less, but by making your body burn more

To allow comparison among the three receptors, this analysis was limited to the 25 ligand interacting (see Supplementary Tables 10 12 for sites) and 17 G-protein interacting sites that were shared by the GCGR and GLP1R sequences (64, 65)