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Malignant melanoma is diagnosed mainly by histopathological examination, which reveals spindle to oval cells with a higher degree of cellular atypia, abundant eosinophilic cytoplasm, large nuclei, and prominent eosinophil nucleoli

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Critical research parameters: reconstitution temperature (ideally 2-8 C), slow injection against the vial wall to avoid shear denaturation, gentle swirling (no aggressive vortex), and complete homogenization before sampling

In an acetic acid-induced UC rat model, the combination treatment exhibited the highest therapeutic efficacy compared to control groups [125]