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The key shift we need The question is no longer: Can patients stop GLP-1s without regaining weight? It is: Which patients can taper, how slowly, with what lifestyle support, and with what monitoring? Until trials are designed to study deprescribing strategies, weight regain after abrupt withdrawal should not be framed as inevitability

While GLP-1 medications offer significant benefits for managing type 2 diabetes, optimizing their effectiveness requires attention to dietary choices and habits

doi: 10.1080/10408398.2021.1986465 129

Search ClinicalTrials.gov for retatrutide Canada to find studies with Canadian sites

Melanotan-2 may be relevant when the hypothesis intentionally includes broader melanocortin receptor biology