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Despite the leaky colon, as determined by electrophysiological measurements and presence of rectally administered FITC-dextran into blood circulation, Cl-2TG mice demonstrated resistance against acute or chronic colitis induced by administering the DSS in drinking water

In fact, acetaminophen-related liver damage is currently the most common cause of liver transplant in the US, with more than 56,000 emergency room visits per year from acetaminophen-related liver problems

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Continuous receptor activation can lead to MC4R desensitization, where the receptor downregulates or becomes less responsive to the ligand