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Mesenchymal cells, transformed from epithelial cells, expressed low level of E-cadherin (an adhesion factor) and high level of Vimentin

This is the MAXXING default recommendation for anyone starting out

IFN- can also activate CD8+ T cells and natural killer (NK) cells to produce perforin and granzymes, inducing programmed cell death of the infected target cells and destruction of the intracellular pathogen

Tretinoin can cause temporary dryness, flaking, or purging during the adjustment period (niacinamide often helps minimize this)

Following PDT, the face can appear red, followed by some flaking and peeling for several days