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It uses nicotinamide, which is linked to the cellular NAD + pathway, and it also uses SAM, which supplies methyl groups for many other reactions in cells

Reversal of diet-induced obesity in mice The defining study, Neelakantan and colleagues in Biochemical Pharmacology (2018), reported that a potent methylquinolinium NNMT inhibitor reduced body weight, white-fat mass, adipocyte size and plasma cholesterol in diet-induced obese mice, without changing food intake or causing overt adverse findings [1]

By inhibiting NNMT, 5-Amino-1MQ preserves NAD+ levels, allowing the coenzyme to activate metabolic health pathwaysparticularly SIRT1 activation, enhanced mitochondrial function, and improved fat oxidation