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Adv Bot Res 1999;30:117205

30 PKA then promotes the synthesis of insulin peptide precursor in beta-pancreatic cells and inhibits the release of glucagon by alpha pancreatic cells

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These structural data reveal a binding mode largely consistent with native amylin, but with notable differences: cagrilintide anchors via the F23 residue and forms a distinctive E14R17 intramolecular salt bridge that stabilizes its receptor-bound conformation