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10.1016/j.biopha.2023.114990 33 Caldern-ParraJ.SantiagoA.DazA

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In murine models, combining the TH-302 nanodrug with PD-1 blockade significantly enhanced antitumor efficacy, leading to greater tumor regression and prolonged survival compared to either treatment alone (306)

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The increase in circulating homocysteine related to impaired homocysteine metabolism may favor the accretion of a pro-oxidant environment by increasing concentrations of free radicals, by maintaining metal ions in their reduced state suitable for the Fenton reaction, and by changing the redox status of intra- and extracellular thiol groups and, hence, the intracellular redox potential (Mansoor et al, 1993a

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