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Yang N, Zhang S, Zhou P, Zhang W, Luo X, Cao J, et al

Eur J Pharmacol 606:205209 Vitvitsky V, Thomas M, Ghorpade A, Gendleman HE, Banerjee R (2006) A functional transulfuration pathway in the brain links to glutathione homeostasis

One domain facilitates the ATP-grasp mechanism [8] and the other is the catalytic active site for -glutamylcysteine

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Furthermore, limited target specificity has been cited as a barrier to its use as a lead compound in drug discovery ( Curcumin demonstrates a substantial ability to interact with and modulate the regulation of various proteins, growth factors, transcription factors, enzymes, receptors, and other regulatory genes through both direct and indirect mechanisms (Sohn et al., 2021)