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Although nicotine was not detected in the Pan Masala samples, data from the National Tobacco Testing Labs (NTTL, India) (The Hindu, April 8, 2015) reveals that it is a leading cause of oral submucous fibrosis that often progresses to oral cancer 10,24

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Even after correction for folate intake, smokers have lower plasma and red blood cell folate concentrations, which suggest that smoking alters folate uptake and metabolism

However, certain sensitive populations may experience more severe acute and chronic symptoms, and even healthy people may experience symptoms