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Each enzyme molecule showed two polar interactions with amlodipine, and they linked through the following residues: for A through arginine (Arg)residues: Arg-252 and Arg-398, for G through Arg-608 and methionine (Met)363, and for SI Arg-58 and Gln-57

DSIP is not unique in its ability to exhibit diurnal variations in antiepileptic activity

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