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In a direct head-to-head comparison, tirzepatide demonstrated similar benefits in reducing MACE as semaglutide
By binding to GLP-1 receptors throughout the body, semaglutide enhances insulin secretion in response to meals, suppresses glucagon release, and slows gastric emptyingthe rate at which food moves from the stomach into the small intestine
The KwikPens have a dose knob, but Lilly labels them as delivering four fixed doses and does not provide a validated click-to-milligram conversion for fractional dosing
The broader receptor activity of tirzepatide may contribute to slightly higher rates of early gastrointestinal intolerance, although discontinuation rates remain comparable 7
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