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If a mole or skin lesion changes in size, shape, colour, or becomes painful, seek professional assessment promptly

Comput Methods Biomech Biomed Eng 27(1):7797

As mentioned, aldehyde may be produced locally in the retina as a result of methanol metabolism

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The post-opening discard period exists because: Sterility can no longer be fully guaranteed after first puncture Preservatives slow microbial growth but do not eliminate contamination risk Risk of contamination increases with repeated vial access For this reason, healthcare and laboratory settings typically follow a fixed discard timeframe (commonly 28 days), unless otherwise specified by the manufacturer