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Acknowledgements This work is supported by National Institute of Health [grant number: R01CA166766 (DMW), P41EB013598 (JK)], and UCSF Department of Radiology and Biomedical Imaging internal grants

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IGF-1 (Insulin-like Growth Factor 1) is produced by the liver in response to circulating GH

Morphological characteristics include reducing or disappearing mitochondrial cristae, small mitochondria with condensed mitochondrial membrane densities, and outer mitochondrial membrane rupture

For example, some studies corroborated this finding of increased serum TBARS levels in BD patients during mania, depression, and euthymia (Andreazza et al., 2007)