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Summary: GLP-1 medications can make you feel cold due to metabolic changes including reduced caloric intake, lower metabolic rate, and loss of insulating subcutaneous fat during weight loss

From there, we may recommend an approved medication as part of a personalized plan or a broader weight management program

Encapsulation of exenatide in poly-(D,L-lactide-co-glycolide) microspheres produced an investigational long-acting once-weekly formulation for type 2 diabetes

While the medication does not directly cause muscle weakness through a neuromuscular mechanism, the combination of fatigue, gastrointestinal symptoms, rapid weight loss, and dietary changes associated with semaglutide therapy creates a clinical context where weakness can reasonably occur as a secondary phenomenon