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5 Natural flavonoids as ferroptosis inhibitors for the therapy of CNS diseases Flavonoids are one of the largest classes of plant polyphenols, characterized by a C6-C3-C6 backbone consisting of three rings labeled as A, B, and C (Dias et al., 2021)

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It activates 1,942 genes (including 47 DNA repair genes and 14 antioxidant genes) and suppresses 762 genes involved in inflammation and fibrosis

TAC1 was enriched in layer 1/2 parvalbumin (PVALB) TAC1 neurons, whilst VGF showed strongest enrichment in layer 2/3/4 vasoactive peptide (VIP) expressing neurons, as well as coexpression with SST in some SST IN populations