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Additionally, extracts from various plant parts have displayed fungicidal effects against several phytopathogenic fungi, underscoring potential applications as natural biofungicides in agriculture [99]

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Moreover, an enormous amount of time, labor, and cost are needed to optimize and improvements needed to translate each stimulus-based NM from the preclinical to clinical stage apart from endogenous triggers such as pH and temperature, as this varies depending from one person to another

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