Candidates for supervised discontinuation: Maintained goal weight on a stable dose for 12 or more months Lost weight primarily through combined medication and lifestyle change (not medication alone) Consume 1.2 to 1.6 g protein per kg body weight daily Perform resistance training 3 or more times per week Sleep 7 or more hours nightly with good sleep architecture Have a BMI at goal of 25 or higher (patients who drop into the low-normal range have less metabolic buffer) No history of binge eating disorder or significant emotional eating patterns Even with this profile, the SURMOUNT-4 data suggests that roughly half of patients will regain meaningful weight within 12 months of stopping (Aronne et al., JAMA 2024)
Before we get into solutions, here are some of the authors takeaways: Symptoms of this severity are rarely attributed to gastroparesis
Tirzepatide (Zepbound / Mounjaro) | The Dual-Receptor Breakthrough How it Works: Tirzepatide is a next-generation peptide that targets both GLP-1 and GIP receptors
DosePop offers physician-prescribed compounded Tirzepatide containing the same active compound
After opening, they can be brought to room temperature (up to 77F) for up to 60 days, however, we suggest keeping it in the refrigerator to protect them from direct sunlight, excessive heat, and freezing temperatures, as these can damage the medication