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It should be pointed out that Griffith [11] originally validated this method in plasma where the artifactual oxidation of GSH is minimal, i.e., tolerable, because the GSH/GSSG ratio in plasma is much lower than in cells (~2 instead of ~400) [3], but this procedure has later been applied broadly to whole blood, red cells or other tissues in which GSH massively exceeds GSSG without proper modification

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In 1982, the basic defect in cystinosis was elucidated as deficient or absent transport of cystine out of lysosomes [4]

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Consistency matters: For steady benefits in sleep quality and regulation of sleep-wake cycles or circadian rhythm, youll typically need to commit to a regular nightly routine rather than expecting dramatic immediate results