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The trial enrolled 2539 patients with a BMI of 30 kg/m2 or greater or 27 kg/m2 plus at least 1 weight-related complication, excluding diabetes, and randomized them in a 1:1:1:1 ratio to their aforementioned treatment options

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GLP-1 agonists upregulate antioxidant enzymes including HO-1 (heme oxygenase-1) and NQO1 (NAD(P)H quinone dehydrogenase 1), providing a counterbalance to the oxidative damage occurring in the pelvis