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J Med Chem 58(18):73707380 Leech CA, Chepurny OG, Holz GG (2010) Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1
Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM (2002) The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia
Caroline shared, Having that reframe allowed me to keep going
Despite a strong mechanistic and preclinical foundation, the clinical application of luteolin has been limited by its poor aqueous solubility, extensive phase II conjugation, and low oral bioavailability (Wang et al., 2024
doi: 10.1007/s12035-023-03737-6
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