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Shao and colleagues discovered that GLP-1 administration restores the balance of inhibitory signaling by enhancing GABA release, thereby promoting RGC survival and improving visual function in early DR

Subsequent studies of human cancer cells xenografted in immunodeficient mice demonstrated that targeted inhibition or depletion of Rlip caused sustained regression of established tumors of small cell lung cancer, nonsmall cell lung cancer, colon cancer, pancreatic cancer, prostate cancer, kidney cancer, and neuroblastoma

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