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doi: 10.1080/10715762.2018.1468564 7 Andriollo-SanchezM.Hininger-FavierI.MeunierN.VenneriaE.OConnorJ

448457, Aug

This avoids square wave exposure (see image below), where hormone levels stay elevated for extended periods in a flat, unnatural pattern

This irreversibly damages the molecule and renders it useless for research

Interestingly, administration of the GHSR1a antagonist JMV2959 or the inverse agonist SP-analog also attenuate the anorexigenic effect caused by D2 agonists, but in this case, the attenuation appeared immediately