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Additionally, dehydration which can occur secondary to the gastrointestinal side effects of GLP-1-based therapies, such as nausea and vomiting may compound the chronotropic effect by triggering a compensatory reflex tachycardia

Cardiovascular outcome trials have established benefits for specific agents: the LEADER trial for liraglutide, SUSTAIN-6 for injectable semaglutide, and REWIND for dulaglutide demonstrated reduced risk of major adverse cardiovascular events in patients with type 2 diabetes

Clin Cancer Res (2012) 18(13):367785

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