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We have to, as educators, help girls and young people identify all of the things about themselves that are wonderful and have nothing to do with their appearance so they have awareness, understanding, and pride in their strengths, characteristics, and competencies, Hinkelman said

Attempting to use a pen device for split dosing introduces unacceptable measurement error

The typical escalation looks like this: Weeks 1 through 4: 0.25 mg per week (adjustment phase, minimal visible effects) Weeks 5 through 8: 0.5 mg per week (appetite suppression becomes more consistent) Weeks 9 through 12: 1.0 mg per week (significant appetite reduction, weight loss accelerates) Weeks 13 through 16: 1.7 mg per week (strong effects for most users) Week 17 onward: 2.4 mg per week (full therapeutic dose) Each dose increase brings a noticeable step up in effect intensity

Other versions of bupropion are approved for smoking cessation and used off-label to treat obesity and ADHD

Acknowledgments We express our sincere gratitude to Professor Kazuyo Tsushita for the distinguished clinical guidance and the expert contributions to the assumptions underpinning the model design