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Tirzepatide, a novel dual agonist of glucose-dependent insulinotropic polypeptide and GLP-1 receptors, 210 combines the satiety-promoting effects of GLP-1 signaling with the increased energy expenditure induced by glucagon
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SUMMIT was the most recent trial investigating cardiovascular outcomes of tirzepatide in patients with obesity and heart failure with preserved ejection fraction (HFpEF)
Cagrilintide also has one of the lowest GI odds ratios among the incretin and amylin compound class in a 2025 Bayesian network meta-analysis of multi-target obesity therapies the relevance for the stack is that adding cagrilintide to retatrutide may not compound GI burden as severely as adding a second GLP-1 agonist would
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