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Vitamin B12 is essential to the human body

[PubMed: 18538282] 108

On the other hand, dose-response relationships for these peptides are often biphasic or bell-shaped, meaning that more is not better and that higher concentrations can lose the effect or even reverse it

However, even subclinical inadequate levels (meaning yet to be diagnosable or evident on lab testing) of some B vitamins may cause fatigue or low energy