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It has a good safety profile, well-tolerated in elderly patients and in patients with co-morbid conditions including risks of cardiovascular event, renal or hepatic insufficiency

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N Engl J Med 359: 285292, 2008 [DOI] [PMC free article] [PubMed] [Google Scholar] 52.Persaud C, McDermott J, De Benoist B, Jackson AA: The excretion of 5-oxoproline in urine, as an index of glycine status, during normal pregnancy

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The discovery of SQORs unique cysteine trisulfide bond cofactor explains its remarkable catalytic efficiency ( 2 S levels, keeping them within an optimal physiological range: on the one hand, genetic defects (e.g., in Leigh syndrome) or CoQ deficiency that abolish SQOR activity can cause toxic H 2 S accumulation, inhibiting the mitochondrial respiratory chain and leading to severe energy failure