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Mice lacking both cytosolic and mitochondrial Aldh, two key enzymes to detoxify DOPAL in the brain, exhibit degeneration of dopaminergic neurons in the SN and development of age-dependent parkinsonian phenotypes [53]

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The index variant is in near perfect linkage disequilibrium ( r 2 = 0.99) with a missense variant within GIPR (rs1800437, P = 5.1 10 9