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Subcutaneous injection of semaglutide has been associated with an increased risk of benign and malignant tumors (including cystic and polypoid forms) and endocrine system disorders such as medullary thyroid carcinoma, thyroid nodules, thyroid follicular carcinoma, neck masses, and tumors of uncertain nature

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This dual-action mechanism is why the two medications are not interchangeable on a day-to-day or week-to-week basis

Semaglutide targets these pathways through medication, and a well-balanced microbiome supports it