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RNR functions by reductive conversion of generally abundant RNA precursors, in the form of ribonucleoside diphosphates (rNDPs), into deoxyribonucleoside diphosphates (dNDPs) (Holmgren et al., 1965

This method facilitates accelerated absorption and produces more immediate results when compared to oral supplements or dietary sources

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Sp could also increase the efficacy of L-DOPA, extensively used in palliative care of PD patients, by subsidence of its long term toxicity

Pfizer also said that acceptance of total impurities in drug substances or total degradation products in drug products should take into account the process and product knowledge, as well as the acceptance criteria for individual impurities