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Kidney Disease: Improving Global Outcomes (KDIGO)

Although coffee and caffeine can increase the risk of cardiovascular disease, numerous studies have demonstrated that coffee and caffeine have hepatoprotective effects against chronic liver diseases ( Camellia sinensis (in the Theaceae family) and includes several varieties, such as green and black tea ( in vitro and in vivo studies on caffeine and EGCG, which provide biological plausibility for their effects ( In the present study, we used a high trans fatty acid/high-carbohydrate (HFHC) diet-induced NASH mouse model to compare the effects of caffeine and EGCG on liver fat metabolism, glucose metabolism, inflammation, and liver fibrosis

Apr 22 2015;63(15):3873-3879

Mitochondrial glutathione: recent insights and role in disease

Localization of Gpx3 to the interstitial ECM was also evident in more distal areas of fibrotic mouse lung, even if less prominent (Supplemental Figure S1)