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Nausea and vomiting, common side effects of GLP-1 therapy, can lead to volume depletion, further straining kidney function when paired with medications that inhibit the renin-angiotensin system (RAAS)

DPP-4 (not described in detail in this article) is the enzyme responsible for degrading native GLP-1 and GIP in the body

Hayes J, McMahon M, Chowdhry S, Dinkova-Kostova A