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Palmoplantar involvement determines a thickening of the palms and soles of leather-like appearance without true hyperkeratosis (Fig

He wrote that smoking tobacco was the most evident of all the retrograde influences of our time. But a couple of centuries earlier (and without the scientific research to back him up), England's King James I was a lot more direct: He wrote that the use of tobacco was a custome loathsome to the eye, hateful to the Nose, harmefull to the braine, dangerous to the Lungs, and the blacke stinking fume thereof, neerest resembling the horrible Stigian smoke of the pit that is bottomelesse. And in 1634 the Russian Czar ordered that people who smoked or sold tobacco would thereafter have their noses slit

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