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To reduce the influence on our model of multiple observations coming from the same study, we adjusted the standard errors of effect sizes reported for multiple non-mutually exclusive exposure groups in each study by a factor matching the number of repeated measurements within each agesexsmoking status group (Supplementary Information Section 2.2)

To sum up While smoking itself does not technically break the intermittent fasting state like getting calories from foods, it can have adverse effects on fasting-related benefits and overall health

Intramural metastasis (IMM) in the esophagus has been found in about 10% of esophageal cancer cases

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