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After a year, the risk of heart disease drops to almost half of a that of a smoker

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In AD, this balance is frequently disrupted, leading to microbial dysbiosis that not only exacerbates local inflammation but also serves as a potential trigger for aberrant activation of the mast cellneuron axis ( Under conditions of barrier disruption or dysbiosis, opportunistic pathogens, most notably Staphylococcus aureus , can overcolonize the skin ( Staphylococcus aureus induces nonIgE-dependent degranulation via a Ca + influxPI3K signaling pathway, and in vivo provokes vascular leakage and eczematous skin lesions