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Tobacco smoke contains over 7,000 harmful chemicals, including three particularly dangerous ones: Nicotine: An addictive stimulant that increases blood pressure, tightens arteries, and makes your heart work harder

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Levels of these biomarkers among smokeless tobacco users were similar to those of never smokers. The study also found that smokeless tobacco users who had formerly been cigarette smokers had lower levels of both inflammatory and oxidative stress biomarkers and tobacco exposure biomarkers than current exclusive cigarettes smokers, even though they had higher nicotine levels