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Liver-derived acylcarnitine can be used as a signal molecule for inter-tissue communication to coordinate energy metabolism, highlighting the role of the liver as a metabolic center, and unveiling the new insight of the liver-organ axis

the hydrophilic spacer linkers described herein include are formed primarily from carbon, hydrogen, and nitrogen, and have a carbon/nitrogen ratio of about 3: 1 or less, or of about 2: 1 or less