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While the origin is unknown, the connection between creatine supplementation and kidney damage/renal dysfunction could be traced back to two things: a poor understanding of creatine and creatinine metabolism and a case study published in 1998. Original study CREATINE

28 Additionally, the method used to diagnose DN affects the reported prevalence

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If no nausea occurs, the dose can be increased by 50-100mcg weekly until reaching 250-500mcg or until clinical endpoints are achieved

Research has shown that Ozempic is more effective than Trulicity in lowering blood sugar levels and decreasing weight, but lower dosages of Ozempic may have a higher risk of side effects compared to lower dosages of Trulicity