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What are the main liver detoxification pathways

The general mechanism of action of combined hormonal contraceptives (estrogens + progestogens) is based on the negative feedback that estrogens induce on the hypothalamus, inhibiting the secretion of gonadotropin release stimulating hormone (GnRH) and, consequently, preventing the increase in the secretion of gonadotrophins by the pituitary to stimulate ovulation in the middle of the cycle

Sharpless, J

Comparing GLP-1 Medications Different GLP-1 medications have slightly different safety profiles

So I do think thats interesting that it does make you, it does make you wonder if you could skip leg day