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Furthermore, L-citrulline blocks this pathological process by suppressing apoptosis and preserving the blood-testis barrier ( Figure 1 2.2 Mitochondrial dysfunction and excessive ROS production Mammalian sperm motility is critically dependent on adenosine triphosphate (ATP), which fuels flagellar movement via the action of dynein ATPase ( Figure 1b ) ( Therefore, interrupting this detrimental cycle necessitates targeted suppression of pathological ROS generation at its mitochondrial source

ChaC2 enhances GSH production by upregulating Nrf2, a key regulator of antioxidation, and its downstream glutamate-cysteine ligase (78)

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Piezo-type mechanosensitive ion channel component 1 (Piezo1) is one of the piezo channels present on the cell membrane and works as a mechanotransducer [115]

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