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Certain, particularly common ABCG2 variants cause renal uric acid underexcretion, extra-renal (small intestinal uric acid underexcretion with renal uric acid overload (and not mediated by uric acid overproduction), an earlier age of onset of gout and decreased urate-lowering response to allopurinol (mediated by altered allopurinol intestinal transport)

Glutathione Content and Expression of Proteins Involved with Glutathione Metabolism Differs in Longissimus Dorsi, Subcutaneous Adipose, and Liver Tissues of Finished vs

J Histochem Cytochem (2015) 63:57591

Some countries with high GC incidence, such as Japan and Korea (Xia and Aadam, 2022), have established screening programs to enhance early detection and overall survival rates