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The STEP UP Phase 3b clinical trial, published in The Lancet Diabetes and Endocrinology in 2025, enrolled over 1,400 adults with obesity and without diabetes

The delay of gastric emptying with semaglutide may influence the absorption of concomitantly administered oral medicinal products [see Drug Interactions (7.2)]

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For broader context on managing these effects, understanding semaglutide-related symptoms provides useful background

If this is happening, it is a good idea to review your injection technique, ensure you are rotating sites properly, and check if you are applying too much pressure with the pen