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Based on the IC 50 data, the chemicals that were the most toxic from high to low were: ethyl maltol, furaneol, maltol, ethyl vanillin, vanillin, and benzyl alcohol

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The intensity of the darkening is influenced by the amount smoked, duration of smoking, and individual skin responses.The good news is that lip pigmentation from smoking is not always permanent

Tennessee was the only Tobacco Nation state to enact local comprehensive smoke-free legislation, bringing the total number of Tobacco Nation states with local smoke-free policies from seven to eight, while outside of Tobacco Nation the number of states with some local comprehensive smoke-free policies has more than doubled