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March 2024 : The US FDA approved a label expansion for WEGOVY based on a supplemental New Drug Application (sNDA) for the indication of reducing risks of major adverse cardiovascular events (MACE), including cardiovascular death, non-fatal heart attack (myocardial infarction), or non-fatal stroke in adults with either overweight or obesity and established CVD

J Endocrinol InvestCedaG

Limitations: As with all GLP-1 therapies, ongoing monitoring for gastrointestinal side effects and potential hypoglycemia (especially in combination with a sulfonylurea) remains crucial

ROS and Ca 2+ regulate the activity of the mitochondrial permeability transition pore (mPTP)

Effect of empagliflozin on erythropoietin levels, iron stores, and red blood cell morphology in patients with type 2 diabetes mellitus and coronary artery disease