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Jackler said that nicotine itself isnt hugely problematic but rather the vehicle that brings the nicotine

This contrasts with previous research suggesting that e-cigarette users may be more inclined to perceive e-cigarettes as cessation aids on the basis of personal experience or community narratives, whereas non-users often rely on public health messages that highlight the lack of conclusive evidence regarding e-cigarettes as effective cessation tools 45

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Smokers tend to take shallower puffs to get a lower dose of nicotine and a stimulant effect, and deeper puffs for a more relaxing experience